منابع مشابه
Targeted destruction of HIV-positive cells
INTRODUCTION HIV/AIDS is now a global epidemic that has become the leading infectious killer of adults worldwide. Although antiretroviral (ARV) therapy has dramatically improved the quality of life and increased the life expectancy of those infected with HIV but frequency of dosing and drug toxicity as well as the development of viral resistance pose additional limitations. The rapidly expandin...
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Microbubble contrast agents can specifically deliver nucleic acids to target tissues when exposed to ultrasound treatment parameters that mediate microbubble destruction. In this study, we evaluated whether microbubbles and ultrasound-targeted microbubble destruction (UTMD) could be used to enhance delivery of EGF receptor (EGFR)-directed siRNA to murine squamous cell carcinomas. Custom-designe...
متن کاملMyocardial delivery of colloid nanoparticles using ultrasound-targeted microbubble destruction.
AIMS Ultrasound (US)-targeted microbubble destruction (UTMD) is a promising method for delivering genetic material to the heart. The aim of this study was: (i) to test whether colloid nanoparticles can be delivered to the rat myocardium using UTMD; and (ii) to determine whether tissue damage and contractile dysfunction occurs in hearts exposed to UTMD in vivo. METHODS AND RESULTS Hearts from ...
متن کاملGLIPR1 suppresses prostate cancer development through targeted oncoprotein destruction.
Downregulation of the proapoptotic p53 target gene glioma pathogenesis-related protein 1 (GLIPR1) occurs frequently in prostate cancer, but the functional meaning of this event is obscure. Here, we report the discovery of functional relationship between GLIPR1 and c-Myc in prostate cancer where c-Myc is often upregulated. We found that the expression of GLIPR1 and c-Myc were inversely correlate...
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Influenza is caused by influenza virus, which outbreaks yearly and causing three to five million illness and about five hundred thousand deaths [1]. The 1918 Spanish Flu killed more than fifty million people, about 5 percent of the total population at the time [2]. The common treatment for influenza is antivirals. However, evidences have shown that antiviral medication can lead to viral resista...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2001
ISSN: 1465-6906
DOI: 10.1186/gb-spotlight-20010724-01